New drugs to strike obesity fast tracked

The FDA has granted new drugs a Fast Track designation to treat obesity, as it has shown comparable potential to gastric bypass surgery.

TENAFLY, NEW JERSEY, UNITED STATES, December 2, 2022 /EINPresswire.com/ -- In October, the US FDA granted Eli Lilly’s Mounjaro (tirzepatide) a Fast Track designation for its use as a treatment for obesity. The drug was approved to treat type 2 diabetes mellitus in May. Mounjaro is the first weight loss drug to show efficacy rates comparable to surgical procedures like sleeve gastrectomies. Several other treatments, like Novo Nordisk’s CagriSema (semaglutide + cagrilintide), are expected to follow after showing encouraging Phase II data.

The UK and US are both undergoing an obesity crisis. The Health Survey for England 2019 reported that 28% of adults in the UK were obese and 36.2% were overweight but not obese. Furthermore, an increase in a sedentary lifestyle, partly brought on by the Covid-19 pandemic, saw a further rise in the obese population. The same can be said for the US. A 2017–2018 National Health and Nutrition Examination Survey (NHANES), showed that 30.7% of adults were overweight, 42.4% were obese, and 9.2% had severe obesity.

In 1997, the World Health Organization (WHO) classified obesity as a chronic disease. High rates of obesity place a major burden on healthcare systems as the condition is associated with many major health complications like type 2 diabetes, hypertension, non-alcoholic fatty liver disease, and other bodily dysfunctions. In the US, obesity care is estimated at to cost $147 billion in healthcare spending annually.

In the past, obesity medications were often dismissed due to insufficient efficacy data and the fact that they were associated with a high occurrence of side effects. However, there has recently been a boom in interest and research in anti-obesity therapeutics. Previously, the standard of care for obesity consisted of holistic changes to diet, exercise, and bariatric surgery for eligible patients. However, despite the effectiveness of bariatric surgery, many obese patients are reluctant to undergo surgical procedures, opening the opportunity for a pharmaceutical approach.

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